On-target and Off-target-based Toxicologic Effects

Off-target cannabinoid effects mediated by GPR55.

Given the vast therapeutic potential of the endocannabinoid system, the revelation of a novel cannabinoid-sensitive target was treated with great excitement. The orphan G-protein coupled receptor 55 (GPR55) was initially touted as a novel cannabinoid target in early industrial patent literature. Consequently, numerous studies have revealed GPR55 expression in a diverse array of cells and tissue...

In Silico Investigation of Off-Target Effects

Controversies in Targeted Therapy of Adult T Cell Leukemia/Lymphoma: ON Target or OFF Target Effects?

Adult T cell leukemia/lymphoma (ATL) represents an ideal model for targeted therapy because of intrinsic chemo-resistance of ATL cells and the presence of two well identified targets: the HTLV-I retrovirus and the viral oncoprotein Tax. The combination of zidovudine (AZT) and interferon-alpha (IFN) has a dramatic impact on survival of ATL patients. Although the mechanism of action remains uncle...

Off-Target? Changing Cognitive-Based Attitudes

Researchers argue that the effectiveness of cognitive versus affective persuasive appeals depends in part on whether the appeal is congruentor incongruentwith a primarily cognitiveor affectiveattitudebase. However, considerableresearchsuggests that these persuasioneffectsmay holdonly for predominantlyaffectiveattitudesand not cognitiveattitudes.Indeed, resultsof Experiment 1 show that the relat...

Target Tracking Based on Virtual Grid in Wireless Sensor Networks

One of the most important and typical application of wireless sensor networks (WSNs) is target tracking. Although target tracking, can provide benefits for large-scale WSNs and organize them into clusters but tracking a moving target in cluster-based WSNs suffers a boundary problem. The main goal of this paper was to introduce an efficient and novel mobility management protocol namely Target Tr...